Carcinoembryonic antigen-related cell adhesion molecule 8

Definition:

Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner. Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Heterophilic interaction with CEACAM8 occurs in activated neutrophils.

References:

[1]. M Kuroki, et al. Identification and comparison of residues critical for cell-adhesion activities of two neutrophil CD66 antigens, CEACAM6 and CEACAM8. J Leukoc Biol. 2001 Oct;70(4):543-50. [Content Brief]

[2]. T Yamanaka, et al. Preparation and characterization of two human carcinoembryonic antigen family proteins of neutrophils, CD66b and c, in silkworm larvae. Protein Expr Purif. 1996 Jun;7(4):438-46. [Content Brief]

[3]. S Oikawa, et al. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. J Biol Chem. 1991 May 5;266(13):7995-8001. [Content Brief]

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