Centriolar coiled-coil protein of 110 kDa

Definition:

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.

References:

[1]. Alexander Spektor, et al. Cep97 and CP110 suppress a cilia assembly program. Cell. 2007 Aug 24;130(4):678-90. [Content Brief]

[2]. Julia Kleylein-Sohn, et al. Plk4-induced centriole biogenesis in human cells. Dev Cell. 2007 Aug;13(2):190-202. [Content Brief]

[3]. Ting Song, et al. ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis. EMBO Rep. 2022 May 4;23(5):e54090. [Content Brief]

[4]. Ji Li, et al. USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110. Nature. 2013 Mar 14;495(7440):255-9. [Content Brief]

[5]. Zhihong Chen, et al. CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev Cell. 2002 Sep;3(3):339-50. [Content Brief]

[6]. William Y Tsang, et al. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. Mol Biol Cell. 2006 Aug;17(8):3423-34. [Content Brief]

[7]. Ning Huang, et al. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Nat Commun. 2018 Oct 30;9(1):4511. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.