Centromere/kinetochore protein zw10 homolog

Definition:

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER.

References:

[1]. Geert J P L Kops, et al. ZW10 links mitotic checkpoint signaling to the structural kinetochore. J Cell Biol. 2005 Apr 11;169(1):49-60. [Content Brief]

[2]. Hidenori Hirose, et al. Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. EMBO J. 2004 Mar 24;23(6):1267-78. [Content Brief]

[3]. Antonio Musio, et al. Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes. Gene. 2004 Apr 28;331:33-40. [Content Brief]

[4]. Hongmei Wang, et al. Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling. J Biol Chem. 2004 Dec 24;279(52):54590-8. [Content Brief]

[5]. F Scaërou, et al. The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore. J Cell Sci. 2001 Sep;114(Pt 17):3103-14. [Content Brief]

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