Centrosomal protein of 131 kDa

Definition:

Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner. Acts also as a negative regulator of BBSome ciliary trafficking. Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells. Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. Essential for maintaining proper centriolar satellite integrity.

References:

[1]. Pavithra L Chavali, et al. Cilia born out of shock and stress. EMBO J. 2013 Nov 27;32(23):3011-3. [Content Brief]

[2]. Susanne Graser, et al. Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol. 2007 Oct 22;179(2):321-30. [Content Brief]

[3]. Christopher J Staples, et al. The centriolar satellite protein Cep131 is important for genome stability. J Cell Sci. 2012 Oct 15;125(Pt 20):4770-9. [Content Brief]

[4]. Bine H Villumsen, et al. A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis. EMBO J. 2013 Nov 27;32(23):3029-40. [Content Brief]

[5]. Andrew Kodani, et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22;4:e07519. [Content Brief]

[6]. Xitiz Chamling, et al. The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome. PLoS Genet. 2014 Feb 13;10(2):e1004083. [Content Brief]

[7]. Ryan A Denu, et al. Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131). J Biol Chem. 2019 Apr 19;294(16):6531-6549. [Content Brief]

[8]. Maxim A X Tollenaere, et al. p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1. Nat Commun. 2015 Nov 30;6:10075. [Content Brief]

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