Centrosomal protein of 164 kDa

Definition:

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.

References:

[1]. Barbara E Tanos, et al. Centriole distal appendages promote membrane docking, leading to cilia initiation. Genes Dev. 2013 Jan 15;27(2):163-8. [Content Brief]

[2]. Susanne Graser, et al. Cep164, a novel centriole appendage protein required for primary cilium formation. J Cell Biol. 2007 Oct 22;179(2):321-30. [Content Brief]

[3]. Sudhakar Sivasubramaniam, et al. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. Genes Dev. 2008 Mar 1;22(5):587-600. [Content Brief]

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