Centrosomal protein of 192 kDa

Definition:

Required for mitotic centrosome maturation and bipolar spindle assembly. Appears to be a major regulator of pericentriolar material (PCM) recruitment, centrosome maturation, and centriole duplication. Centrosome-specific activating scaffold for AURKA and PLK1.

References:

[1]. Fei Zhu, et al. The mammalian SPD-2 ortholog Cep192 regulates centrosome biogenesis. Curr Biol. 2008 Jan 22;18(2):136-41. [Content Brief]

[2]. Maria Ana Gomez-Ferreria, et al. Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol. 2007 Nov 20;17(22):1960-6. [Content Brief]

[3]. Vladimir Joukov, et al. The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly. Mol Cell. 2014 Aug 21;55(4):578-91. [Content Brief]

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