Centrosomal protein of 78 kDa

Definition:

May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis.

References:

[1]. Kathrin Brunk, et al. Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication. J Cell Sci. 2016 Jul 15;129(14):2713-8. [Content Brief]

[2]. Konstantinos Nikopoulos, et al. Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss Associated with Primary-Cilia Defects. Am J Hum Genet. 2016 Sep 1;99(3):770-776. [Content Brief]

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