Centrosomal protein of 97 kDa

Definition:

Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.

References:

[1]. Alexander Spektor, et al. Cep97 and CP110 suppress a cilia assembly program. Cell. 2007 Aug 24;130(4):678-90. [Content Brief]

[2]. Ning Huang, et al. M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole. Nat Commun. 2018 Oct 30;9(1):4511. [Content Brief]

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