Cilia- and flagella-associated protein 58

Definition:

Has an essential role in the assembly and organization of the sperm flagellar axoneme. Required for the elongation of the primary cilium and sperm flagellar midpiece via modulation of the Notch signaling pathway (By similarity).

References:

[1]. Xiaojin He, et al. Bi-allelic Loss-of-function Variants in CFAP58 Cause Flagellar Axoneme and Mitochondrial Sheath Defects and Asthenoteratozoospermia in Humans and Mice. Am J Hum Genet. 2020 Sep 3;107(3):514-526. [Content Brief]

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