Cytosolic purine 5'-nucleotidase

Definition

Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell.

References:

[1]. M G Tozzi, et al. Nucleoside phosphotransferase activity of human colon carcinoma cytosolic 5'-nucleotidase. Arch Biochem Biophys. 1991 Dec;291(2):212-7. [Content Brief]

[2]. S Allegrini, et al. Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and expression of active enzyme in Escherichia coli. Biochem J. 1997 Dec 1;328 ( Pt 2)(Pt 2):483-7. [Content Brief]

[3]. Cristina Mazzon, et al. Cytosolic and mitochondrial deoxyribonucleotidases: activity with substrate analogs, inhibitors and implications for therapy. Biochem Pharmacol. 2003 Aug 1;66(3):471-9. [Content Brief]

[4]. J Spychala, et al. ATP and phosphate reciprocally affect subunit association of human recombinant High Km 5'-nucleotidase. Role for the C-terminal polyglutamic acid tract in subunit association and catalytic activity. Eur J Biochem. 1999 Feb;259(3):851-8. [Content Brief]

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