Dedicator of cytokinesis protein 4

Definition:

Functions as a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form. Involved in regulation of adherens junction between cells. Plays a role in cell migration.; [Isoform 2]: Has a higher guanine nucleotide exchange factor activity compared to other isoforms.

References:

[1]. Vijay Yajnik, et al. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell. 2003 Mar 7;112(5):673-84. [Content Brief]

[2]. Nao Hiramoto-Yamaki, et al. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J Cell Biol. 2010 Aug 9;190(3):461-77. [Content Brief]

[3]. D Yan, et al. An isoform of GTPase regulator DOCK4 localizes to the stereocilia in the inner ear and binds to harmonin (USH1C). J Mol Biol. 2006 Mar 31;357(3):755-64. [Content Brief]

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