Double-strand-break repair protein rad21 homolog

Definition:

[Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (By similarity). May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter. May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity).; [64-kDa C-terminal product]: May promote apoptosis.

References:

[1]. Debananda Pati, et al. Linking sister chromatid cohesion and apoptosis: role of Rad21. Mol Cell Biol. 2002 Dec;22(23):8267-77. [Content Brief]

[2]. Feng Chen, et al. Caspase proteolysis of the cohesin component RAD21 promotes apoptosis. J Biol Chem. 2002 May 10;277(19):16775-81. [Content Brief]

[3]. H C Gregson, et al. A potential role for human cohesin in mitotic spindle aster assembly. J Biol Chem. 2001 Dec 14;276(50):47575-82. [Content Brief]

[4]. S Hauf, et al. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science. 2001 Aug 17;293(5533):1320-3. [Content Brief]

[5]. Elena Bonora, et al. Mutations in RAD21 disrupt regulation of APOB in patients with chronic intestinal pseudo-obstruction. Gastroenterology. 2015 Apr;148(4):771-782.e11. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.