E3 SUMO-protein ligase ZBED1

Definition:

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins.; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.

References:

[1]. Daisuke Yamashita, et al. Transcription Factor hDREF Is a Novel SUMO E3 Ligase of Mi2α. J Biol Chem. 2016 May 27;291(22):11619-34. [Content Brief]

[2]. Daisuke Yamashita, et al. hDREF regulates cell proliferation and expression of ribosomal protein genes. Mol Cell Biol. 2007 Mar;27(6):2003-13. [Content Brief]

[3]. Sandi Radko, et al. Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth. J Virol. 2014 Nov;88(22):13469-81. [Content Brief]

[4]. Nobuko Ohshima, et al. Identification of a human homologue of the DREF transcription factor with a potential role in regulation of the histone H1 gene. J Biol Chem. 2003 Jun 20;278(25):22928-38. [Content Brief]

[5]. Daisuke Yamashita, et al. Human DNA replication-related element binding factor (hDREF) self-association via hATC domain is necessary for its nuclear accumulation and DNA binding. J Biol Chem. 2007 Mar 9;282(10):7563-75. [Content Brief]

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