E3 ubiquitin-protein ligase FANCL

Definition:

Ubiquitin ligase protein that mediates monoubiquitination of FANCD2 in the presence of UBE2T, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.

References:

[1]. Amom Ruhikanta Meetei, et al. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet. 2003 Oct;35(2):165-70. [Content Brief]

[2]. Simonne Longerich, et al. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. J Biol Chem. 2009 Aug 28;284(35):23182-6. [Content Brief]

[3]. Yuichi J Machida, et al. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. Mol Cell. 2006 Aug;23(4):589-96. [Content Brief]

[4]. Arno F Alpi, et al. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. Mol Cell. 2008 Dec 26;32(6):767-77. [Content Brief]

[5]. Charlotte Hodson, et al. Structure of the human FANCL RING-Ube2T complex reveals determinants of cognate E3-E2 selection. Structure. 2014 Feb 4;22(2):337-44. [Content Brief]

[6]. Arno Alpi, et al. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. Mol Cell Biol. 2007 Dec;27(24):8421-30. [Content Brief]

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