E3 ubiquitin-protein ligase PPP1R11

Definition:

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.

References:

[1]. Alison C McKelvey, et al. RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. Elife. 2016 Nov 2;5:e18496. [Content Brief]

[2]. J Zhang, et al. Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. Biochemistry. 1998 Nov 24;37(47):16728-34. [Content Brief]

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