E3 ubiquitin-protein ligase ZFP91

Definition:

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

References:

[1]. Motoko Unoki, et al. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Int J Oncol. 2003 Jun;22(6):1217-23. [Content Brief]

[2]. Xuejun Jin, et al. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. J Biol Chem. 2010 Oct 1;285(40):30539-47. [Content Brief]

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