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  2. Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

Definition:

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation.

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