Giant cell tumor of bone

Definition

Giant-cell tumor of bone (GCTB) is a rare osteolytic tumor of the bone. Although classified as a benign tumor, GCTB is characterized by local aggressiveness and risk of local recurrence. Its name is derived from the numerous multinucleated giant cells found within the tumor, which are principally responsible for the extensive bone resorption that is characteristic of GCTB. However, the neoplastic components of GCTB are the spindle-like stromal cells, which produce RANKL that recruits monocytic osteoclast precursors from blood to the tumor, and stimulates differentiation into multinucleated giant cells. Recently, denosumab (RANKL inhibitor) has become a new treatment option for locally advanced GCTB.

References:

[1]. Armelle Dufresne, et al. Giant-cell tumor of bone, anti-RANKL therapy. Bonekey Rep. 2012 Sep 5;1:149. [Content Brief]

[2]. Keith M Skubitz, et al. Giant cell tumor of bone: current treatment options. Curr Treat Options Oncol. 2014 Sep;15(3):507-18. [Content Brief]

[3]. Lizz van der Heijden, et al. The clinical approach toward giant cell tumor of bone. Oncologist. 2014 May;19(5):550-61. [Content Brief]

[4]. Robert W Cowan, et al. Giant cell tumor of bone: a basic science perspective. Bone. 2013 Jan;52(1):238-46. [Content Brief]

生物医学辞典

生物医学辞典は、生物学の学術用語と専門データの包括的で専門的なデータベースです。すべての説明は、権威ある書籍や高いＩＦの文献に基づいており、知りたい生物医学用語の正確な説明を得ることができます。

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