Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase

Definition:

Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. That protein has no CMP-N-acetylneuraminate monooxygenase activity and is not able to convert CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells in vertebrates. However, it may play a role in Wnt signaling.

References:

[1]. A Irie, et al. The molecular basis for the absence of N-glycolylneuraminic acid in humans. J Biol Chem. 1998 Jun 19;273(25):15866-71. [Content Brief]

[2]. H H Chou, et al. A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11751-6. [Content Brief]

[3]. T Hayakawa, et al. Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11399-404. [Content Brief]

[4]. Johanna Nystedt, et al. Human CMP-N-acetylneuraminic acid hydroxylase is a novel stem cell marker linked to stem cell-specific mechanisms. Stem Cells. 2010 Feb;28(2):258-67. [Content Brief]

[5]. Hsun-Hua Chou, et al. Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11736-41. [Content Brief]

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