Intrahepatic cholestasis of pregnancy

Definition:

Intrahepatic cholestasis of pregnancy (ICP), also called obstetric cholestasis, is the most common pregnancy-specific liver disease. Classic symptoms include generalized pruritus that commonly includes the palms and soles, and biochemical evidence of elevated bile acids, with or without elevated liver function tests (LFTs). The etiology of ICP is influenced by a combination of genetic, endocrine, and environmental factors. Risk factors for ICP include multiple pregnancy, in vitro fertilization, advanced maternal age, history of prior affected pregnancy, positive family history, and hepatitis C infection.

References:

[1]. Amber M Wood, et al. Intrahepatic Cholestasis of Pregnancy: A Review of Diagnosis and Management. Obstet Gynecol Surv. 2018 Feb;73(2):103-109. [Content Brief]

[2]. Caroline Ovadia, et al. Intrahepatic cholestasis of pregnancy: Recent advances. Clin Dermatol. 2016 May-Jun;34(3):327-34. [Content Brief]

[3]. J M de Vree, et al. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):282-7. [Content Brief]

[4]. R Müllenbach, et al. ATP8B1 mutations in British cases with intrahepatic cholestasis of pregnancy. Gut. 2005 Jun;54(6):829-34. [Content Brief]

[5]. Saraid McIlvride, et al. Bile acids and gestation. Mol Aspects Med. 2017 Aug;56:90-100. [Content Brief]

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