Lysosomal acid lipase/cholesteryl ester hydrolase

Definition

Catalyzes the deacylation of triacylglyceryl and cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol.

References:

[1]. Oliver Zschenker, et al. Lysosomal acid lipase as a preproprotein. J Biochem. 2004 Jul;136(1):65-72. [Content Brief]

[2]. D Ameis, et al. Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase. Eur J Biochem. 1994 Feb 1;219(3):905-14. [Content Brief]

[3]. T G Warner, et al. Purification of the lysosomal acid lipase from human liver and its role in lysosomal lipid hydrolysis. J Biol Chem. 1981 Mar 25;256(6):2952-7. [Content Brief]

[4]. R A Anderson, et al. Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases. J Biol Chem. 1991 Nov 25;266(33):22479-84. [Content Brief]

[5]. S Ries, et al. Different missense mutations in histidine-108 of lysosomal acid lipase cause cholesteryl ester storage disease in unrelated compound heterozygous and hemizygous individuals. Hum Mutat. 1998;12(1):44-51. [Content Brief]

生物医学辞典

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