Mediator of RNA polymerase II transcription subunit 12

Definition

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

References:

[1]. Haiying Zhou, et al. Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol Cell Biol. 2006 Dec;26(23):8667-82. [Content Brief]

[2]. Seokjoong Kim, et al. Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem. 2006 May 19;281(20):14066-75. [Content Brief]

[3]. Hwa Jin Baek, et al. Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J Biol Chem. 2006 Jun 2;281(22):15172-81. [Content Brief]

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