Metastasis-associated in colon cancer protein 1

Definition:

Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.

References:

[1]. Ulrike Stein, et al. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med. 2009 Jan;15(1):59-67. [Content Brief]

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