2. Biology Dictionary
  3. Mitogen-activated protein kinase kinase kinase 12

Mitogen-activated protein kinase kinase kinase 12

Definition:

Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway.

Biomedical Dictionary

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