Mitogen-activated protein kinase kinase kinase 21

Definition:

Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.

References:

[1]. Alim Seit-Nebi, et al. MLK4 has negative effect on TLR4 signaling. Cell Mol Immunol. 2012 Jan;9(1):27-33. [Content Brief]

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