Mixed lineage leukemia protein-1 (MLL1) (also called MLL/KMT2A/HRX/HTRX/ALL1)

Definition:

Mixed lineage leukemia protein-1 (MLL1), a histone methyltransferase and transcription factor, is critical for epigenetic maintenance of Hox gene expression, and is required for normal fetal and adult hematopoiesis. MLL1 is located at chromosome 11q23 which cause acute leukemia.

References:

[1]. Xu J, et al. MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program. Cell Discov. 2016 May 17;2:16008. [Content Brief]

[2]. Li X, et al. Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins. J Hematol Oncol. 2021 Apr 6;14(1):56. [Content Brief]

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