N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

Definition:

Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells.; [Isoform C]: Determines the expression of the blood group I antigen in erythrocytes.

References:

[1]. Niro Inaba, et al. A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expression. Blood. 2003 Apr 1;101(7):2870-6. [Content Brief]

[2]. M F Bierhuizen, et al. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. Genes Dev. 1993 Mar;7(3):468-78. [Content Brief]

[3]. M F Bierhuizen, et al. Genomic organization of core 2 and I branching beta-1,6-N-acetylglucosaminyltransferases. Implication for evolution of the beta-1,6-N-acetylglucosaminyltransferase gene family. Glycobiology. 1995 Jun;5(4):417-25. [Content Brief]

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