Non-receptor tyrosine-protein kinase TNK1

Definition:

Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction.

References:

[1]. Sarasija Hoare, et al. Tnk1/Kos1 knockout mice develop spontaneous tumors. Cancer Res. 2008 Nov 1;68(21):8723-32. [Content Brief]

[2]. D M Felschow, et al. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1. Biochem Biophys Res Commun. 2000 Jun 24;273(1):294-301. [Content Brief]

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