Ras-GEF domain-containing family member 1A

Definition:

Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, KRAS, HRAS, and NRAS (in vitro). Plays a role in cell migration.

References:

[1]. Katsuaki Ura, et al. Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma. Clin Cancer Res. 2006 Nov 15;12(22):6611-6. [Content Brief]

[2]. Elif Yaman, et al. RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. FEBS J. 2009 Aug;276(16):4607-16. [Content Brief]

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