Ras-related protein Rab-30

Definition

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins.

References:

[1]. Eoin E Kelly, et al. Rab30 is required for the morphological integrity of the Golgi apparatus. Biol Cell. 2012 Feb;104(2):84-101. [Content Brief]

生物医学辞典

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