Regulator of G-protein signaling 2

Definition:

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.

References:

[1]. Chau H Nguyen, et al. Translational control by RGS2. J Cell Biol. 2009 Sep 7;186(5):755-65. [Content Brief]

[2]. S P Heximer, et al. Mechanisms governing subcellular localization and function of human RGS2. J Biol Chem. 2001 Apr 27;276(17):14195-203. [Content Brief]

[3]. Adam J Kimple, et al. Structural determinants of G-protein alpha subunit selectivity by regulator of G-protein signaling 2 (RGS2). J Biol Chem. 2009 Jul 17;284(29):19402-11. [Content Brief]

[4]. M L Cunningham, et al. Protein kinase C phosphorylates RGS2 and modulates its capacity for negative regulation of Galpha 11 signaling. J Biol Chem. 2001 Feb 23;276(8):5438-44. [Content Brief]

[5]. Hoa T N Phan, et al. Human Missense Mutations in Regulator of G Protein Signaling 2 Affect the Protein Function Through Multiple Mechanisms. Mol Pharmacol. 2017 Oct;92(4):451-458. [Content Brief]

[6]. Steven Gu, et al. Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins. Mol Pharmacol. 2008 Jan;73(1):1-11. [Content Brief]

[7]. H K Wu, et al. Differential expression of a basic helix-loop-helix phosphoprotein gene, G0S8, in acute leukemia and localization to human chromosome 1q31. Leukemia. 1995 Aug;9(8):1291-8. [Content Brief]

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