Regulator of G-protein signaling 7

Definition:

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.

References:

[1]. Rachel A Hunt, et al. Snapin interacts with the N-terminus of regulator of G protein signaling 7. Biochem Biophys Res Commun. 2003 Apr 4;303(2):594-9. [Content Brief]

[2]. T Benzing, et al. 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. J Biol Chem. 2000 Sep 8;275(36):28167-72. [Content Brief]

[3]. Ryan M Drenan, et al. Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol. 2005 May 23;169(4):623-33. [Content Brief]

[4]. B A Posner, et al. Regulators of G protein signaling 6 and 7. Purification of complexes with gbeta5 and assessment of their effects on g protein-mediated signaling pathways. J Biol Chem. 1999 Oct 22;274(43):31087-93. [Content Brief]

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