Regulatory solute carrier protein family 1 member 1

Definition:

Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network.

References:

[1]. S Lambotte, et al. The human gene of a protein that modifies Na(+)-D-glucose co-transport. DNA Cell Biol. 1996 Sep;15(9):769-77. [Content Brief]

[2]. Maike Veyhl, et al. RS1 (RSC1A1) regulates the exocytotic pathway of Na+-D-glucose cotransporter SGLT1. Am J Physiol Renal Physiol. 2006 Dec;291(6):F1213-23. [Content Brief]

[3]. M Veyhl, et al. Downregulation of the Na(+)- D-glucose cotransporter SGLT1 by protein RS1 (RSC1A1) is dependent on dynamin and protein kinase C. J Membr Biol. 2003 Nov 1;196(1):71-81. [Content Brief]

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