Required for drug-induced death protein 1

Definition:

Regulates drug efflux through modulation of ABCB1 localization and activity.

References:

[1]. Man-Tat Lau, et al. Systematic functional identification of cancer multi-drug resistance genes. Genome Biol. 2020 Feb 7;21(1):27. [Content Brief]

[2]. Sanna N Masud, et al. Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux. Nat Chem Biol. 2022 Dec;18(12):1370-1379. [Content Brief]

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