Rho-related GTP-binding protein RhoU

Definition:

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

References:

[1]. Adam Shutes, et al. Biochemical analyses of the Wrch atypical Rho family GTPases. Methods Enzymol. 2006;406:11-26. [Content Brief]

[2]. W Tao, et al. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev. 2001 Jul 15;15(14):1796-807. [Content Brief]

[3]. Siau Wei Bai, et al. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. BMC Biol. 2011 Aug 11;9:54. [Content Brief]

[4]. Aino Ruusala, et al. The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics. Mol Cell Biol. 2008 Mar;28(5):1802-14. [Content Brief]

[5]. Stéphane Ory, et al. Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration. Biol Cell. 2007 Dec;99(12):701-16. [Content Brief]

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