Ribosomal L1 domain-containing protein 1

Definition:

Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage.

References:

[1]. Liwei Ma, et al. CSIG inhibits PTEN translation in replicative senescence. Mol Cell Biol. 2008 Oct;28(20):6290-301. [Content Brief]

[2]. N Li, et al. Nucleolar protein CSIG is required for p33ING1 function in UV-induced apoptosis. Cell Death Dis. 2012 Mar 15;3(3):e283. [Content Brief]

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