RNA-splicing ligase RtcB homolog

Definition:

Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.

References:

[1]. Johannes Popow, et al. HSPC117 is the essential subunit of a human tRNA splicing ligase complex. Science. 2011 Feb 11;331(6018):760-4. [Content Brief]

[2]. Johannes Popow, et al. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. Nature. 2014 Jul 3;511(7507):104-7. [Content Brief]

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