Serine/threonine-protein kinase SIK2

Definition

Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL. Also plays a role in thymic T-cell development (By similarity).

References:

[1]. Zhen-Ning Zhang, et al. SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300. Sci Rep. 2016 Mar 17;6:23317. [Content Brief]

[2]. Robert A Screaton, et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell. 2004 Oct 1;119(1):61-74. [Content Brief]

[3]. Fu-Chia Yang, et al. Reversible acetylation regulates salt-inducible kinase (SIK2) and its function in autophagy. J Biol Chem. 2013 Mar 1;288(9):6227-37. [Content Brief]

[4]. Julien Bricambert, et al. Salt-inducible kinase 2 links transcriptional coactivator p300 phosphorylation to the prevention of ChREBP-dependent hepatic steatosis in mice. J Clin Invest. 2010 Dec;120(12):4316-31. [Content Brief]

生物医学辞典

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