Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

Definition:

As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.

References:

[1]. Joseph T Rodgers, et al. Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt. Mol Cell. 2011 Feb 18;41(4):471-9. [Content Brief]

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