Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

Definition

Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

References:

[1]. Bjarki Stefansson, et al. Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains. Biochemistry. 2008 Feb 5;47(5):1442-51. [Content Brief]

[2]. Nicole C Kwiek, et al. PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. Cell Signal. 2006 Oct;18(10):1769-78. [Content Brief]

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