Signal peptide, CUB and EGF-like domain-containing protein 2

Definition:

Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.

References:

[1]. Guilherme M Xavier, et al. Hedgehog receptor function during craniofacial development. Dev Biol. 2016 Jul 15;415(2):198-215. [Content Brief]

[2]. Petra Jakobs, et al. Scube2 enhances proteolytic Shh processing from the surface of Shh-producing cells. J Cell Sci. 2014 Apr 15;127(Pt 8):1726-37. [Content Brief]

[3]. Adrian Creanga, et al. Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev. 2012 Jun 15;26(12):1312-25. [Content Brief]

[4]. Hanna Tukachinsky, et al. Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep. 2012 Aug 30;2(2):308-20. [Content Brief]

[5]. Yuh-Charn Lin, et al. Endothelial SCUBE2 Interacts With VEGFR2 and Regulates VEGF-Induced Angiogenesis. Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):144-155. [Content Brief]

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