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  2. Signal transducer and activator of transcription (STAT)

Signal transducer and activator of transcription (STAT)

Definition:

Signal transducer and activator of transcription (STAT) is a 7-member family of cytoplasmic protein that regulates many aspects of growth, survival and differentiation in cells. The transcription factors of this family are activated by Janus kinase and dysregulation of this pathway is frequently observed in primary tumours and leads to increased angiogenesis, enhanced survival of tumours and immunosuppression.

Biomedical Dictionary

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