Sister chromatid cohesion protein PDS5 homolog A

Definition:

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

References:

[1]. Marie-Emilie Terret, et al. Cohesin acetylation speeds the replication fork. Nature. 2009 Nov 12;462(7270):231-4. [Content Brief]

[2]. Ana Losada, et al. Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. J Cell Sci. 2005 May 15;118(Pt 10):2133-41. [Content Brief]

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