Solute carrier family 12 member 6

Definition:

[Isoform 1]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable).; [Isoform 2]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable).; [Isoform 3]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable).; [Isoform 4]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable).; [Isoform 5]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable).; [Isoform 6]: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells (Probable).

References:

[1]. Adriana Mercado, et al. NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter. Am J Physiol Renal Physiol. 2005 Dec;289(6):F1246-61. [Content Brief]

[2]. J E Race, et al. Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter. Am J Physiol. 1999 Dec;277(6):C1210-9. [Content Brief]

[3]. Ximin Chi, et al. Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters. Cell Res. 2021 Apr;31(4):482-484. [Content Brief]

[4]. Gamma Chi, et al. Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. EMBO J. 2021 Jul 15;40(14):e107294. [Content Brief]

[5]. S Casula, et al. A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem. 2001 Nov 9;276(45):41870-8. [Content Brief]

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