Solute carrier family 2, facilitated glucose transporter member 7

Definition:

Probable sugar transporter. Even if its physiological substrate is subject to discussion, it is able to transport glucose and fructose. Does not transport galactose, 2-deoxy-d-glucose and xylose.

References:

[1]. Karolin Ebert, et al. Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters. J Membr Biol. 2017 Apr;250(2):171-182. [Content Brief]

[2]. Julia S Gauer, et al. Differential patterns of inhibition of the sugar transporters GLUT2, GLUT5 and GLUT7 by flavonoids. Biochem Pharmacol. 2018 Jun;152:11-20. [Content Brief]

[3]. Qiang Li, et al. Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G236-42. [Content Brief]

[4]. Andrei Manolescu, et al. Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7). J Biol Chem. 2005 Dec 30;280(52):42978-83. [Content Brief]

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