Solute carrier family 22 member 12

Definition

Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions. Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid. Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate. Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent.

References:

[1]. Velibor Tasic, et al. Clinical and functional characterization of URAT1 variants. PLoS One. 2011;6(12):e28641. [Content Brief]

[2]. Daisaku Miura, et al. Human urate transporter 1 (hURAT1) mediates the transport of orotate. J Physiol Sci. 2011 May;61(3):253-7. [Content Brief]

[3]. Atsushi Enomoto, et al. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature. 2002 May 23;417(6887):447-52. [Content Brief]

[4]. Yu Toyoda, et al. OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. Front Pharmacol. 2022 Apr 6;13:842717. [Content Brief]

[5]. Yutaro Shinoda, et al. Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. Drug Metab Pharmacokinet. 2022 Apr;43:100443. [Content Brief]

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