Solute carrier organic anion transporter family member 4A1

Definition:

Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, taurocholate, estrone 3-sulfate, estradiol-17beta-glucuronide and prostaglandin E2 (PGE2). Shows a pH-sensitive substrate specificity T4 and estrone 3-sulfate which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions.

References:

[1]. Simone Leuthold, et al. Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters. Am J Physiol Cell Physiol. 2009 Mar;296(3):C570-82. [Content Brief]

[2]. I Tamai, et al. Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. [Content Brief]

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