Tumor necrosis factor receptor superfamily member 10D

Definition

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

References:

[1]. S A Marsters, et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol. 1997 Dec 1;7(12):1003-6. [Content Brief]

[2]. G Pan, et al. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett. 1998 Mar 6;424(1-2):41-5. [Content Brief]

[3]. M A Degli-Esposti, et al. The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity. 1997 Dec;7(6):813-20. [Content Brief]

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