U3 small nucleolar RNA-associated protein 25 homolog

Definition:

Component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing (By similarity). Essential for embryonic development in part through the regulation of p53 pathway. Controls the expansion growth of digestive organs and liver. Also involved in the sympathetic neuronal development (By similarity). Mediates, with CAPN3, the proteasome-independent degradation of p53/TP53.

References:

[1]. Ting Tao, et al. Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Res. 2013 May;23(5):620-34. [Content Brief]

[2]. Hao Lei, et al. MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease. BMC Gastroenterol. 2014 Jul 9;14:123. [Content Brief]

[3]. Yihong Guan, et al. Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3. PLoS Biol. 2016 Sep 22;14(9):e1002555. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.