Ubiquitin-associated domain-containing protein 2

Definition:

Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6.

References:

[1]. Jin Huk Choi, et al. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Science. 2019 May 10;364(6440):eaau0812. [Content Brief]

[2]. James A Olzmann, et al. Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1345-50. [Content Brief]

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